palmitoylcholine to arachidonoylcholine

Numerator Metabolite

Structure of palmitoylcholine
Metabolite Accession: GCST90200071
Name: palmitoylcholine
Hmdb Id: HMDB0240592
Super Pathway: NA
Sub Pathway: NA
Inchikey: ODYPFMHOOQOHEF

Denominator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.178
Position:
61588305
SE (Ratio):
0.007
Effect Allele:
G
Z-score (Ratio):
26.197
Reference Allele:
A
-log10(P):
-346.641
MAF:
0.344
Beta (Num):
-0.014
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.193
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Acyl-choline metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Acyl-choline metabolism

Ratio Explanation:

The ratio of palmitoylcholine to arachidonoylcholine reflects the activity of fatty acid desaturase enzymes, with a higher ratio suggesting lower desaturase efficiency.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters the efficiency of polyunsaturated fatty acid synthesis, reflected in the palmitoylcholine/arachidonoylcholine ratio. This dysregulation of lipid metabolism is associated with an increased risk for hypercholesterolemia and other inflammatory and metabolic disorders like cholelithiasis and type 2 diabetes.5[1], 6[2], 7[3], 8[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data