palmitoylcholine to dihomo-linolenoyl-choline

Numerator Metabolite

Structure of palmitoylcholine
Metabolite Accession: GCST90200071
Name: palmitoylcholine
Hmdb Id: HMDB0240592
Super Pathway: NA
Sub Pathway: NA
Inchikey: ODYPFMHOOQOHEF

Denominator Metabolite

Structure of dihomo-linolenoyl-choline
Metabolite Accession: GCST90200090
Name: dihomo-linolenoyl-choline
Hmdb Id: HMDB0240646
Super Pathway: NA
Sub Pathway: NA
Inchikey: CPIZQONKXRTJBX

Associated Genomic Regions

Region: rs174559

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.102
Position:
61581656
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-7.816
Reference Allele:
G
-log10(P):
-32.842
MAF:
0.273
Beta (Num):
-0.014
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.088
SE (Den):
0.019
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism; Phospholipid metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid metabolism; PUFA biosynthesis.3[1], 6[2], 5[3]

Ratio Explanation:

The ratio reflects FADS desaturase activity, balancing saturated (palmitoylcholine) versus polyunsaturated (dihomo-linolenoyl-choline) fatty acid choline esters. Lower FADS activity decreases the denominator.1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the balance of pro- and anti-inflammatory PUFAs, impacting lipid profiles.8[1], 9[2] This genetically-driven imbalance is linked to hypercholesterolemia, other lipoprotein disorders, and inflammatory conditions like asthma and sinusitis.10[3], 8[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data