1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)* to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs17231506

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.153
Position:
56994528
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
8.647
Reference Allele:
C
-log10(P):
-39.780
MAF:
0.326
Beta (Num):
0.097
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.056
SE (Den):
0.016
No CNV overlap
rQTL cluster:
26
Reaction Distance:
NA
Closest Genes:
CETP HERPUD1 NLRC5 SLC12A3 NUP93

Region: rs8736

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.224
Position:
54677189
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
13.086
Reference Allele:
C
-log10(P):
-88.421
MAF:
0.436
Beta (Num):
0.050
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.174
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.9[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylinositol biosynthesis.10[1], 11[2], 12[3]

Ratio Explanation:

The ratio likely reflects altered lipoprotein metabolism driven by CETP, impacting the relative abundance of phosphatidylcholine and phosphatidylinositol species on different lipoprotein particles.5[1], 8[2], 13[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in CETP are associated with altered plasma lipid profiles and an increased risk for age-related macular degeneration.14[1], 15[2], 16[3], 17[4] This altered lipid environment, reflected by the PC/PI ratio, likely contributes to lipid deposition and inflammation in the macula.18[5]

Phenotype Driver:

Gene-centric:CETP

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data