1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs3764261

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.132
Position:
56993324
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
8.306
Reference Allele:
C
-log10(P):
-36.849
MAF:
0.328
Beta (Num):
0.094
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.038
SE (Den):
0.016
No CNV overlap
rQTL cluster:
26
Reaction Distance:
NA
Closest Genes:
CETP HERPUD1 NLRC5 SLC12A3 NUP93

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio of a diacyl-phosphatidylcholine to a lysophosphatidylcholine may reflect lipoprotein remodeling activity, influenced by CETP-mediated lipid transfers between HDL and other lipoproteins.3[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in CETP alters its lipid transfer activity, which remodels lipoproteins like HDL and LDL, reflected by the PC/LPC ratio.5[1], 3[2] This altered lipoprotein metabolism is a known causal factor for dyslipidemia and atherosclerotic cardiovascular diseases such as myocardial infarction.1[3], 6[4], 7[5]

Phenotype Driver:

Gene-centric:CETP

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data