1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)* to 1-oleoyl-gpe (18:1)

Numerator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Denominator Metabolite

Structure of 1-oleoyl-gpe (18:1)
Metabolite Accession: GCST90199794
Name: 1-oleoyl-gpe (18:1)
Hmdb Id: HMDB0011506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PYVRVRFVLRNJLY

Associated Genomic Regions

Region: rs102274

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.376
Position:
61557826
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-21.138
Reference Allele:
T
-log10(P):
-226.687
MAF:
0.338
Beta (Num):
-0.298
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.078
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Arachidonic acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.6[1], 7[2]

Ratio Explanation:

This ratio reflects FADS1/FADS2 enzyme activity, comparing a key product of arachidonic acid synthesis (in the numerator) to another common phospholipid (in the denominator).8[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS cluster alters enzyme activity, influencing the ratio of polyunsaturated fatty acids. This dysregulation of lipid metabolism is linked to phenotypes like cholelithiasis, hypercholesterolemia, and other disorders of lipoprotein metabolism observed in the associated traits.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data