1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)* to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.645
Position:
61581764
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-35.433
Reference Allele:
T
-log10(P):
-631.541
MAF:
0.306
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.331
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid and fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Phospholipid and fatty acid biosynthesis.3[1]

Ratio Explanation:

The ratio reflects FADS1 enzyme activity, comparing a phosphatidylcholine with the precursor fatty acid (dihomo-linolenoyl) to one with the product fatty acid (arachidonoyl).

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 alter enzyme activity, impacting the balance of pro-inflammatory and anti-inflammatory polyunsaturated fatty acids. This dysregulation of fatty acid metabolism is linked to phenotypes like asthma, hypercholesterolemia, and various inflammatory conditions.2[1], 4[2], 5[3], 6[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data