1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)* to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)

Numerator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Associated Genomic Regions

Region: rs102274

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.504
Position:
61557826
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-26.596
Reference Allele:
T
-log10(P):
-357.175
MAF:
0.338
Beta (Num):
-0.298
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.206
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylinositol metabolism.5[1], 6[2]

Ratio Explanation:

This ratio reflects FADS1/FADS2 desaturase activity, comparing the abundance of an arachidonic acid-containing PC (product) to a linoleic acid-containing PI (precursor-related).2[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters desaturase activity, impacting the balance of polyunsaturated fatty acids like arachidonic acid.7[1], 8[2] This dysregulates lipid metabolism and inflammation, contributing to increased risk for cholelithiasis, altered cholesterol, and inflammatory conditions like asthma, all observed phenotypes.9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data