1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)* to 1,2-dilinoleoyl-gpe (18:2/18:2)*

Numerator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Denominator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Associated Genomic Regions

Region: rs174535

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.527
Position:
61551356
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
-23.498
Reference Allele:
T
-log10(P):
-279.467
MAF:
0.342
Beta (Num):
-0.298
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.229
SE (Den):
0.018
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid Metabolism, Glycerophospholipid Metabolism

Denominator Metabolite Explanation:

Phospholipid Metabolism, Glycerophospholipid Metabolism

Ratio Explanation:

The ratio reflects FADS enzyme activity, specifically the conversion of linoleic acid (18:2) into arachidonic acid (20:4n6), which are then incorporated into different phospholipids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter the production of long-chain fatty acids, influencing lipid profiles and inflammatory responses.2[1], 5[2], 6[3], 7[4], 8[5] This dysregulation is linked to hypercholesterolemia, cholelithiasis, and asthma, which are observed as associated phenotypes.9[6], 10[7], 11[8], 12[9], 13[10], 14[11]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data