1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)* to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*

Numerator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Denominator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.426
Position:
61557803
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-22.969
Reference Allele:
T
-log10(P):
-267.153
MAF:
0.344
Beta (Num):
-0.299
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.127
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Phosphatidylinositol biosynthesis6[1], 7[2]

Ratio Explanation:

The ratio reflects FADS-mediated synthesis of arachidonic acid (a component of the numerator) relative to other lipids, indicating pro-inflammatory potential.2[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the production of arachidonic acid-containing phospholipids.9[1], 10[2] This impacts the balance of inflammatory and anti-inflammatory mediators, influencing susceptibility to inflammatory conditions like asthma and IBD, and disorders of lipid metabolism such as hypercholesterolemia and cholelithiasis.11[3], 12[4], 13[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data