1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)* to 1-oleoyl-2-docosahexaenoyl-gpc (18:1/22:6)*

Numerator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Denominator Metabolite

Structure of 1-oleoyl-2-docosahexaenoyl-gpc (18:1/22:6)*
Metabolite Accession: GCST90200081
Name: 1-oleoyl-2-docosahexaenoyl-gpc (18:1/22:6)*
Hmdb Id: HMDB0008123
Super Pathway: NA
Sub Pathway: NA
Inchikey: FPEVDFOXMCHLKL

Associated Genomic Regions

Region: rs28444611

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.206
Position:
11040767
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
10.042
Reference Allele:
T
-log10(P):
-52.960
MAF:
0.240
Beta (Num):
0.106
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.100
SE (Den):
0.017
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SMIM13 SYCP2L ERVFRD-1 RP11-637O19.3

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid remodeling, omega-6 fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Phospholipid remodeling, omega-3 and omega-9 fatty acid metabolism.6[1]

Ratio Explanation:

This ratio reflects the balance between phosphatidylcholines containing omega-6 versus omega-3 and omega-9 fatty acids, which is influenced by ELOVL2 activity.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data