1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)* to 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*

Numerator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Denominator Metabolite

Metabolite Accession: GCST90200082
Name: 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*
Hmdb Id: HMDB0005349
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102274

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.692
Position:
61557826
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-33.412
Reference Allele:
T
-log10(P):
-561.909
MAF:
0.338
Beta (Num):
-0.298
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.394
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism5[1], 6[2]

Ratio Explanation:

The ratio reflects FADS1/FADS2 enzymatic activity, converting linoleic acid (18:2) to its product arachidonic acid (20:4n6) within different glycerophospholipid backbones.1[1], 7[2], 8[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters PUFA synthesis, reflected by the ratio. This dysregulates lipid metabolism and inflammation, increasing risk for associated phenotypes like cholelithiasis, dyslipidemia, and asthma by altering arachidonic acid-derived signaling molecules.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data