1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)* to nisinate (24:6n3)

Numerator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Denominator Metabolite

Structure of nisinate (24:6n3)
Metabolite Accession: GCST90200122
Name: nisinate (24:6n3)
Hmdb Id: HMDB0013025
Super Pathway: NA
Sub Pathway: NA
Inchikey: YHGJECVSSKXFCJ

Associated Genomic Regions

Region: rs28444611

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
0.250
Position:
11040767
SE (Ratio):
0.029
Effect Allele:
G
Z-score (Ratio):
8.555
Reference Allele:
T
-log10(P):
-38.980
MAF:
0.240
Beta (Num):
0.106
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
-0.144
SE (Den):
0.024
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SMIM13 SYCP2L ERVFRD-1 RP11-637O19.3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, omega-6 PUFA synthesis.2[1], 3[2]

Denominator Metabolite Explanation:

Omega-3 very-long-chain PUFA synthesis.1[1], 4[2]

Ratio Explanation:

This ratio reflects the balance between omega-6 (numerator) and omega-3 (denominator) very-long-chain fatty acid synthesis, pathways where ELOVL2 plays a key enzymatic role.5[1], 6[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Due to the absence of associated phenotype data, a causal link between the ELOVL2 gene, the specified metabolite ratio, and any potential phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data