1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)* to n-acetyl-2-aminooctanoate*

Numerator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Denominator Metabolite

Structure of n-acetyl-2-aminooctanoate*
Metabolite Accession: GCST90200183
Name: n-acetyl-2-aminooctanoate*
Hmdb Id: HMDB0059745
Super Pathway: NA
Sub Pathway: NA
Inchikey: JJGNMSOJTSABGA

Associated Genomic Regions

Region: rs1871395

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.212
Position:
21352315
SE (Ratio):
0.028
Effect Allele:
G
Z-score (Ratio):
7.640
Reference Allele:
A
-log10(P):
-31.461
MAF:
0.157
Beta (Num):
0.108
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.104
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine biosynthesis

Denominator Metabolite Explanation:

Fatty acid metabolism

Ratio Explanation:

The ratio may reflect altered hepatic transport by SLCO1B1, impacting both the clearance of bilirubin-related compounds and fatty acid derivatives.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function can lead to increased bilirubin and altered lipid levels, contributing to hyperbilirubinemia-related phenotypes (MCH, MCV, TBil) and potentially gout and dyslipidemia (TG).3[1], 4[2], 5[3]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data