1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)* to stearidonate (18:4n3)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.292
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
12.755
Reference Allele:
C
-log10(P):
-84.126
MAF:
0.339
Beta (Num):
0.171
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.121
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis9[1], 10[2], 11[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis3[1], 12[2], 13[3], 14[4]

Ratio Explanation:

The ratio reflects FADS2 activity, which synthesizes stearidonate (denominator) and metabolizes linoleic acid, a component of the plasmalogen numerator, impacting PUFA balance.2[1], 3[2], 6[3], 15[4], 16[5]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity dysregulates polyunsaturated fatty acid metabolism, impacting inflammatory and lipid pathways. This connects genetic factors to phenotypes like cholelithiasis, type 2 diabetes, and inflammatory bowel disease, which are influenced by inflammation and lipid profiles.17[1], 7[2], 8[3], 18[4], 19[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data