1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174544

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.279
Position:
61567753
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
12.606
Reference Allele:
C
-log10(P):
-82.217
MAF:
0.301
Beta (Num):
0.164
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.115
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.3[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid signaling.4[1]

Ratio Explanation:

The ratio reflects the activity of FADS enzymes, comparing a plasmalogen containing the PUFA linoleoyl (18:2) to a lysophospholipid with the saturated fatty acid stearoyl (18:0).1[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS activity influences the balance of polyunsaturated and saturated fatty acids within different phospholipid classes.1[1], 5[2] This shift impacts lipid metabolism and inflammatory pathways, contributing to phenotypes like hypercholesterolemia, asthma, and cholelithiasis.6[3], 7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data