1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)* to 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*
Metabolite Accession: GCST90200048
Name: 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*
Hmdb Id: HMDB0011352
Super Pathway: NA
Sub Pathway: NA
Inchikey: UUYSKERSKRMYME

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.254
Position:
61569830
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
19.265
Reference Allele:
C
-log10(P):
-188.763
MAF:
0.339
Beta (Num):
0.171
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.083
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen and glycerophospholipid biosynthesis.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Plasmalogen and glycerophospholipid biosynthesis.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects the conversion of linoleic acid (18:2) to arachidonic acid (20:4), a key step in fatty acid metabolism mediated by FADS enzymes.10[1], 11[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the metabolite ratio, is associated with altered lipid profiles (e.g., higher triglycerides, varied cholesterol levels), and increased risk for inflammatory conditions and cardiovascular disease, including cholelithiasis and hypercholesterolemia.3[1], 12[2], 13[3], 14[4], 15[5], 16[6], 17[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data