1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)* to 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.310
Position:
61593816
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
13.048
Reference Allele:
C
-log10(P):
-87.924
MAF:
0.338
Beta (Num):
0.171
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.139
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen synthesis.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio reflects FADS activity, where lower levels of the numerator's linoleoyl (18:2) moiety relative to the denominator's arachidonoyl (20:4) moiety suggest higher desaturase efficiency.11[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter the balance of omega-6 fatty acids, such as the ratio of linoleic acid (18:2) to arachidonic acid (20:4), which is associated with disorders of lipoprotein metabolism and inflammatory conditions like IBD.2[1], 12[2], 13[3], 14[4] This influences phenotypes like pure hypercholesterolemia.13[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data