1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)* to sphingomyelin (d17:2/16:0, d18:2/15:0)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Denominator Metabolite

Metabolite Accession: GCST90200125
Name: sphingomyelin (d17:2/16:0, d18:2/15:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174580

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.247
Position:
61606642
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
12.643
Reference Allele:
A
-log10(P):
-82.698
MAF:
0.350
Beta (Num):
0.171
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.076
SE (Den):
0.014
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen synthesis.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Sphingolipid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio reflects FADS-mediated desaturation activity, influencing the fatty acid composition of complex lipids and the balance between plasmalogen and sphingomyelin pools.1[1], 3[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS genes alters polyunsaturated fatty acid metabolism, a key process in both lipid homeostasis and inflammation.11[1], 12[2] This dysregulation can drive associated phenotypes like hypercholesterolemia, cholelithiasis, and asthma, with the ratio reflecting this altered metabolic state.13[3], 14[4], 15[5], 16[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data