1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)* to sphingomyelin (d18:2/21:0, d16:2/23:0)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Denominator Metabolite

Metabolite Accession: GCST90200129
Name: sphingomyelin (d18:2/21:0, d16:2/23:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174580

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.255
Position:
61606642
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
12.446
Reference Allele:
A
-log10(P):
-80.208
MAF:
0.350
Beta (Num):
0.171
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.084
SE (Den):
0.013
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Glycerophospholipid metabolism5[1], 6[2]

Denominator Metabolite Explanation:

Sphingolipid metabolism7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid and sphingolipid pools, influenced by FADS-mediated PUFA synthesis for incorporation into the plasmalogen numerator.1[1], 11[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS gene variants alter PUFA desaturation, affecting the composition of membrane lipids like plasmalogens and influencing inflammatory and lipid metabolic pathways tied to cholelithiasis and hypercholesterolemia.1[1], 12[2], 13[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data