1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)* to docosatrienoate (22:3n6)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.362
Position:
61569830
SE (Ratio):
0.028
Effect Allele:
T
Z-score (Ratio):
13.062
Reference Allele:
C
-log10(P):
-88.111
MAF:
0.339
Beta (Num):
0.171
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.190
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Ether lipid metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Linoleic acid metabolism, PUFA biosynthesis.1[1], 6[2], 7[3]

Ratio Explanation:

The ratio reflects FADS-mediated conversion of linoleic acid (in numerator) to downstream PUFAs (denominator), with a higher ratio indicating lower desaturase pathway efficiency.8[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variation alters PUFA synthesis, reflected by the ratio.8[1], 10[2] This change in the balance of PUFAs, which are precursors to inflammatory mediators, influences lipid levels and inflammatory conditions like asthma, IBD, and cholelithiasis.10[3], 11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data