1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)* to arachidonoylcarnitine (c20:4)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Denominator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.438
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
18.869
Reference Allele:
C
-log10(P):
-181.192
MAF:
0.339
Beta (Num):
0.171
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.266
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis

Denominator Metabolite Explanation:

Fatty acid beta-oxidation / Carnitine shuttle

Ratio Explanation:

This ratio reflects FADS1/FADS2 desaturase efficiency, contrasting a lipid with a precursor fatty acid (linoleic acid) to a product derivative (arachidonoylcarnitine).5[1], 1[2], 4[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Variation in FADS genes alters the balance of polyunsaturated fatty acids.5[1], 1[2], 6[3] This dysregulates pro-inflammatory arachidonic acid production, contributing to phenotypes like asthma, cholelithiasis, and hypercholesterolemia by modulating inflammation and lipid metabolism.7[4], 8[5], 9[6], 10[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data