1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.410
Position:
61557803
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
18.869
Reference Allele:
T
-log10(P):
-181.194
MAF:
0.347
Beta (Num):
0.161
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.249
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid biosynthesis, Fatty acid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism

Ratio Explanation:

The ratio reflects FADS1 (delta-5 desaturase) activity, where lower FADS1 function decreases the conversion of precursors to products like arachidonic acid, altering lipid composition.1[1], 3[2], 2[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, indicated by the metabolite ratio, is linked to altered inflammatory and lipid profiles, which are associated with valvular heart disease and disorders of lipoprotein metabolism.1[1], 4[2], 5[3], 6[4], 2[5], 7[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data