1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to stearidonate (18:4n3)

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.288
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
12.687
Reference Allele:
C
-log10(P):
-83.258
MAF:
0.340
Beta (Num):
0.167
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.121
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Plasmalogen synthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Omega-3 fatty acid synthesis, PUFA metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects FADS2 delta-6 desaturase activity, comparing an omega-6 containing plasmalogen with an omega-3 PUFA, indicating the omega-6/omega-3 metabolic balance.1[1], 10[2], 11[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters the balance of omega-3 and omega-6 PUFA synthesis, reflected by the ratio. This imbalance influences inflammatory and metabolic processes, contributing to phenotypes like cholelithiasis, asthma, and altered plasma lipids.3[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data