1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to stearoylcarnitine (c18)

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of stearoylcarnitine (c18)
Metabolite Accession: GCST90199743
Name: stearoylcarnitine (c18)
Hmdb Id: HMDB0000848
Super Pathway: NA
Sub Pathway: NA
Inchikey: FNPHNLNTJNMAEE

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.232
Position:
61593816
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
12.114
Reference Allele:
C
-log10(P):
-76.105
MAF:
0.339
Beta (Num):
0.167
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.065
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen synthesis, Glycerophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle.6[1], 7[2]

Ratio Explanation:

This ratio may reflect the balance between ether phospholipid synthesis incorporating polyunsaturated fatty acids (PUFAs) and fatty acid oxidation, influenced by FADS desaturase activity.8[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene variants alter desaturase activity, affecting the balance of fatty acids available for either plasmalogen synthesis or beta-oxidation. This dysregulation of lipid metabolism is linked to phenotypes like hypercholesterolemia, cholelithiasis, and other inflammatory and metabolic disorders.8[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data