1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to 1-arachidonylglycerol (20:4)

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.435
Position:
61588305
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
18.942
Reference Allele:
A
-log10(P):
-182.569
MAF:
0.344
Beta (Num):
0.164
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.271
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Ether phospholipid metabolism, Glycerophospholipid metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Endocannabinoid signaling, Arachidonic acid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio of a linoleoyl-containing plasmalogen to an arachidonic acid-containing monoacylglycerol may reflect FADS-mediated polyunsaturated fatty acid synthesis.1[1], 4[2], 10[3], 7[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid metabolism.4[1] This dysregulation can impact inflammatory and lipid pathways, contributing to phenotypes like cholelithiasis, type 2 diabetes, and inflammatory conditions such as asthma and IBD.11[2], 12[3], 13[4], 14[5], 15[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data