1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs174577

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.241
Position:
61604814
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
12.051
Reference Allele:
C
-log10(P):
-75.335
MAF:
0.349
Beta (Num):
0.164
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.077
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis5[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism6[1]

Ratio Explanation:

The ratio reflects the conversion of 1-stearoyl-GPE (18:0) to a plasmalogen, a process influenced by the availability of linoleic acid and FADS activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants influence fatty acid desaturation,1[1], 2[2] affecting plasmalogen levels. This dysregulation of lipid metabolism is linked to an increased risk for follicular cysts of the skin,7[3], 8[4] potentially through altered cell membrane composition or inflammatory pathways.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data