1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174570

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.398
Position:
61597212
SE (Ratio):
0.032
Effect Allele:
T
Z-score (Ratio):
12.422
Reference Allele:
C
-log10(P):
-79.910
MAF:
0.131
Beta (Num):
0.236
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
-0.162
SE (Den):
0.023
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis3[1], 4[2], Glycerophospholipid metabolism5[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis6[1], 7[2]

Ratio Explanation:

This ratio compares a plasmalogen containing linoleic acid (18:2) to a downstream metabolite (22:5n6), reflecting the metabolic flux and efficiency of FADS2/FADS1 enzymes.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid metabolism.8[1], 9[2] This dysregulation is linked to disorders of lipid metabolism, such as hypercholesterolemia, and other phenotypes including type 2 diabetes and skin neoplasms, likely through impacts on inflammation and cellular membrane composition.1[3], 10[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data