1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Metabolite Accession: GCST90200045
Name: 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Hmdb Id: HMDB0009003
Super Pathway: NA
Sub Pathway: NA
Inchikey: ANRKEHNWXKCXDB

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.391
Position:
61593816
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
16.839
Reference Allele:
C
-log10(P):
-144.837
MAF:
0.339
Beta (Num):
0.167
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.224
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen synthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylserine decarboxylation pathway.5[1], 6[2]

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2, where linoleoyl (18:2) in the numerator is a precursor to arachidonoyl (20:4) in the denominator.1[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by a higher ratio, alters polyunsaturated fatty acid balance. This dysregulation is linked to altered cholesterol metabolism and inflammation, contributing to phenotypes like pure hypercholesterolemia and cholelithiasis, as supported by PheWAS and MR data.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data