1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4)*
Metabolite Accession: GCST90200052
Name: 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4)*
Hmdb Id: HMDB0011220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IOYKZPNDXIIXLN

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.637
Position:
61557803
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
34.390
Reference Allele:
T
-log10(P):
-595.108
MAF:
0.347
Beta (Num):
0.161
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.476
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Phospholipid biosynthesis

Denominator Metabolite Explanation:

Ether lipid metabolism, Phospholipid biosynthesis

Ratio Explanation:

The ratio reflects the relative activity of FADS1/FADS2 in desaturating fatty acids, influencing the balance between different classes of ether-linked and ester-linked phospholipids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster influence the activity of FADS1 and FADS2, altering the balance of polyunsaturated fatty acids. This dysregulation of lipid metabolism is associated with an increased risk of cholelithiasis (gallstones) and hypercholesterolemia, conditions linked to altered bile composition and lipid levels.5[1], 6[2], 7[3], 8[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data