1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Metabolite Accession: GCST90200079
Name: 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Hmdb Id: HMDB0009069
Super Pathway: NA
Sub Pathway: NA
Inchikey: PECSWFQRRFRZPW

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.288
Position:
61592362
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
12.246
Reference Allele:
A
-log10(P):
-77.725
MAF:
0.345
Beta (Num):
0.165
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.123
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid biosynthesis.5[1], 6[2]

Ratio Explanation:

This ratio reflects FADS1/FADS2 enzymatic activity, comparing a phospholipid with the precursor linoleic acid (18:2) to one with the product arachidonic acid (20:4).7[1], 8[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, impacting the balance of pro- and anti-inflammatory fatty acids.10[1], 11[2] This dysregulation is linked to inflammatory phenotypes like asthma and metabolic conditions such as cholelithiasis and hypercholesterolemia.12[3], 13[4], 14[5], 15[6], 16[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data