1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to arachidonoylcholine

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Associated Genomic Regions

Region: rs99780

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.358
Position:
61596633
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
15.547
Reference Allele:
C
-log10(P):
-123.829
MAF:
0.346
Beta (Num):
0.164
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.193
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis, Cholinergic signaling.5[1], 6[2]

Ratio Explanation:

The ratio reflects the conversion of linoleic acid (18:2) in the numerator to arachidonic acid (20:4) in the denominator, a process mediated by FADS enzymes.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS activity, indicated by a higher ratio, alters the balance of pro-inflammatory (arachidonic acid-derived) and other lipid mediators. This dysregulation is linked to inflammatory conditions and altered lipid profiles, including cholelithiasis, hypercholesterolemia, and asthma, which are observed phenotypes.5[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data