1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to sphingomyelin (d17:2/16:0, d18:2/15:0)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Metabolite Accession: GCST90200125
Name: sphingomyelin (d17:2/16:0, d18:2/15:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174580

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.241
Position:
61606642
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
13.062
Reference Allele:
A
-log10(P):
-88.110
MAF:
0.351
Beta (Num):
0.166
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.076
SE (Den):
0.014
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.4[1]

Denominator Metabolite Explanation:

Sphingolipid metabolism.5[1], 6[2]

Ratio Explanation:

This ratio may reflect FADS2 activity, which influences the availability of linoleic acid for incorporation into plasmalogens versus the synthesis of sphingomyelin.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS2 gene variants alter polyunsaturated fatty acid (PUFA) levels, affecting the ratio of this plasmalogen to sphingomyelin.7[1], 8[2] This lipid imbalance is associated with metabolic phenotypes, including cholelithiasis, altered cholesterol levels, and type 2 diabetes, by impacting membrane composition and inflammatory pathways.9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:[FADS2]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data