1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to sphingomyelin (d18:2/21:0, d16:2/23:0)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Metabolite Accession: GCST90200129
Name: sphingomyelin (d18:2/21:0, d16:2/23:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174580

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.249
Position:
61606642
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
12.532
Reference Allele:
A
-log10(P):
-81.292
MAF:
0.351
Beta (Num):
0.166
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.084
SE (Den):
0.013
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Sphingolipid metabolism, ceramide synthesis.6[1], 7[2]

Ratio Explanation:

This ratio may reflect FADS-mediated fatty acid desaturation, influencing the balance between linoleic acid-containing plasmalogens and sphingomyelins, two key membrane lipid classes.8[1], 9[2], 10[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

FADS gene variants alter fatty acid metabolism, reflected by the ratio. This dysregulation of PUFA and membrane lipid composition can drive inflammation and metabolic dysfunction, contributing to phenotypes like hypercholesterolemia, type 2 diabetes, and asthma, which are strongly associated with FADS activity.11[1], 12[2], 13[3], 14[4], 15[5], 16[6]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data