1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to docosatrienoate (22:3n6)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.358
Position:
61569830
SE (Ratio):
0.027
Effect Allele:
T
Z-score (Ratio):
13.142
Reference Allele:
C
-log10(P):
-89.162
MAF:
0.340
Beta (Num):
0.167
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.190
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen and glycerophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.6[1], 7[2]

Ratio Explanation:

The ratio reflects FADS2 activity, where lower activity leads to an accumulation of precursors like 1-(1-enyl-stearoyl)-2-linoleoyl-gpe and a decrease in products like docosatrienoate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FADS2 activity, indicated by the ratio, is associated with altered lipid profiles and an increased risk for cholelithiasis and type 2 diabetes.8[1], 9[2], 10[3] This alteration in fatty acid metabolism can contribute to the development of insulin resistance and changes in bile composition.11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data