1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to arachidonoylcarnitine (c20:4)

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.434
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
18.678
Reference Allele:
C
-log10(P):
-177.599
MAF:
0.340
Beta (Num):
0.167
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.266
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, Beta-oxidation.5[1]

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2, where higher activity leads to increased arachidonic acid (denominator) from precursors like linoleic acid (in the numerator).1[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS activity, indicated by a higher ratio, is linked to altered lipid profiles and inflammatory phenotypes like asthma and IBD.7[1], 8[2], 9[3] This altered fatty acid metabolism influences cell membrane composition and pro-inflammatory mediator production, contributing to disease risk.10[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data