1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.378
Position:
61588305
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
20.085
Reference Allele:
A
-log10(P):
-204.940
MAF:
0.344
Beta (Num):
0.131
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.246
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs8736

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
0.331
Position:
54677189
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
17.954
Reference Allele:
C
-log10(P):
-164.289
MAF:
0.436
Beta (Num):
0.157
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.174
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis

Denominator Metabolite Explanation:

GPI anchor biosynthesis

Ratio Explanation:

The ratio indicates the relative activity of FADS, which produces arachidonic acid (20:4), and MBOAT7, which incorporates available fatty acids into GPI anchors.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced MBOAT7 or FADS1/2 activity alters the 18:0/18:1 to 18:0/20:4 GPI anchor ratio, impacting inflammatory pathways and lipid metabolism, contributing to phenotypes like Cholelithiasis and Inflammatory bowel disease.5[1], 6[2], 7[3], 8[4]

Phenotype Driver:

Gene-centric:FADS1/MBOAT7

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data