1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to stearidonate (18:4n3)

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.251
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
11.575
Reference Allele:
A
-log10(P):
-69.668
MAF:
0.344
Beta (Num):
0.131
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.120
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, GPI anchor biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects FADS desaturase activity; FADS1/FADS2 convert precursors into PUFAs like stearidonate and influence the fatty acid composition of complex lipids like glycerophosphoinositols.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variations in FADS1/FADS2 alter PUFA metabolism, impacting circulating lipid levels and inflammatory processes.7[1], 9[2] This dysregulation is associated with lipoprotein metabolism disorders, cholelithiasis, and inflammatory conditions like asthma and sinusitis, which are linked phenotypes.7[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data