1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs28456

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.234
Position:
61589481
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
12.613
Reference Allele:
A
-log10(P):
-82.308
MAF:
0.309
Beta (Num):
0.122
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.112
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism.3[1]

Denominator Metabolite Explanation:

Lysophospholipid metabolism.4[1], 5[2]

Ratio Explanation:

The ratio reflects fatty acid desaturation activity, potentially influenced by FADS1, contrasting a complex unsaturated GPI lipid with a simpler saturated lysophospholipid.1[1], 6[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters its desaturase activity, impacting the balance of polyunsaturated fatty acids.6[1], 7[2] This dysregulation is linked to inflammatory conditions like asthma and dermatitis, and metabolic disorders such as hypercholesterolemia and cholelithiasis.8[3], 9[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data