1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to 1-palmitoyl-gpc (16:0)

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-palmitoyl-gpc (16:0)
Metabolite Accession: GCST90199733
Name: 1-palmitoyl-gpc (16:0)
Hmdb Id: HMDB0010382
Super Pathway: NA
Sub Pathway: NA
Inchikey: ASWBNKHCZGQVJV

Associated Genomic Regions

Region: rs174536

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.195
Position:
61551927
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
10.774
Reference Allele:
A
-log10(P):
-60.647
MAF:
0.341
Beta (Num):
0.127
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.068
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis.6[1], 7[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.8[1], 9[2]

Ratio Explanation:

This ratio reflects the balance between a specific GPI anchor and a lysophospholipid, influenced by FADS1/FADS2 activity on fatty acid precursors.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid metabolism, which is linked to inflammatory and metabolic phenotypes like hypercholesterolemia and cholelithiasis.4[1], 10[2], 11[3] The ratio likely acts as a biomarker for this altered lipid metabolism and resulting inflammatory state.

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data