1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to stearoylcarnitine (c18)

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of stearoylcarnitine (c18)
Metabolite Accession: GCST90199743
Name: stearoylcarnitine (c18)
Hmdb Id: HMDB0000848
Super Pathway: NA
Sub Pathway: NA
Inchikey: FNPHNLNTJNMAEE

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.197
Position:
61579463
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
10.001
Reference Allele:
A
-log10(P):
-52.548
MAF:
0.337
Beta (Num):
0.130
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.067
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI) anchor biosynthesis.2[1], 3[2], 4[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Ratio Explanation:

The ratio reflects stearic acid's metabolic fate, comparing its incorporation into GPI anchors versus its entry into mitochondrial beta-oxidation, modulated by FADS activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters fatty acid desaturation, affecting lipid metabolism and inflammatory responses.1[1], 7[2], 8[3], 9[4] This dysregulation is linked to hypercholesterolemia and inflammatory conditions like cholelithiasis, which are associated phenotypes.10[5], 11[6], 12[7], 13[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data