1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.206
Position:
61592362
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
11.751
Reference Allele:
A
-log10(P):
-71.743
MAF:
0.345
Beta (Num):
0.130
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.075
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects fatty acid desaturase activity, where higher FADS1/FADS2 function increases the oleoyl (18:1) moiety in GPI, relative to stearoyl-GPE.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters fatty acid desaturase activity, influencing the balance of saturated and unsaturated fatty acids in lipids.10[1], 11[2] This dysregulation of lipid metabolism is a known risk factor for cholelithiasis, hypercholesterolemia, and can modulate inflammatory responses seen in asthma.12[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data