1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.244
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
10.493
Reference Allele:
C
-log10(P):
-57.637
MAF:
0.339
Beta (Num):
0.131
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.113
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis9[1], 10[2], 11[3]

Ratio Explanation:

The ratio reflects the balance between glycerophosphoinositol lipids and the biosynthesis of long-chain polyunsaturated fatty acids, which is influenced by FADS1/FADS2 enzymatic activity.3[1], 12[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the metabolite ratio, alters lipid profiles, which is associated with an increased risk for valvular heart disease, inflammatory bowel disease, and disorders of lipoprotein metabolism.13[1], 14[2], 15[3], 16[4], 17[5], 18[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data