1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Metabolite Accession: GCST90200045
Name: 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Hmdb Id: HMDB0009003
Super Pathway: NA
Sub Pathway: NA
Inchikey: ANRKEHNWXKCXDB

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.355
Position:
61593005
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
16.261
Reference Allele:
A
-log10(P):
-135.229
MAF:
0.346
Beta (Num):
0.132
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.224
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA metabolism.6[1], 7[2]

Ratio Explanation:

Reflects FADS enzyme efficiency, comparing a lipid with a precursor fatty acid (18:1) to a lipid containing a downstream product, arachidonic acid (20:4).8[1], 9[2], 10[3], 11[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 function, reflected by the ratio, impacts polyunsaturated fatty acid levels, which dysregulates lipid metabolism and inflammation.12[1], 13[2], 14[3], 15[4] This is linked to the observed phenotypes, including cholelithiasis, hypercholesterolemia, type 2 diabetes, and various inflammatory and cardiovascular conditions.16[5], 17[6], 18[7], 19[8], 20[9], 21[10], 22[11], 23[12]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data