1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.270
Position:
61593005
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
12.748
Reference Allele:
A
-log10(P):
-84.031
MAF:
0.346
Beta (Num):
0.132
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.139
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis.7[1], 8[2]

Ratio Explanation:

The ratio reflects the relative activity of glycerophosphoinositol and phosphatidylethanolamine synthesis, with FADS1/FADS2 influencing the arachidonic acid (20:4) component of the denominator.1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1 and FADS2 are associated with altered fatty acid metabolism and levels of triglycerides, cholesterol (HDL, LDL), and are linked to cholelithiasis and other lipid metabolism disorders.9[1], 10[2], 11[3], 12[4] This suggests that genetically influenced changes in fatty acid desaturation impact lipid profiles and gallstone risk.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data