1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Metabolite Accession: GCST90200060
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Hmdb Id: HMDB0011211
Super Pathway: NA
Sub Pathway: NA
Inchikey: QLEHHUPUHJPURI

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.243
Position:
116648917
SE (Ratio):
0.028
Effect Allele:
G
Z-score (Ratio):
8.724
Reference Allele:
C
-log10(P):
-40.454
MAF:
0.131
Beta (Num):
0.127
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
-0.117
SE (Den):
0.023
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI) anchor biosynthesis.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Ether lipid / Plasmalogen biosynthesis.8[1], 9[2], 10[3], 11[4]

Ratio Explanation:

This ratio likely reflects altered lipoprotein lipid composition, driven by apolipoprotein gene function, rather than a direct enzymatic relationship between the distinct lipid classes.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variants in the apolipoprotein gene cluster (APOA5/A1) alter lipoprotein metabolism, causing dyslipidemia and increasing cardiovascular disease risk.12[1], 3[2], 13[3] This systemic lipid dysregulation, reflected in the ratio, is a primary driver for phenotypes like myocardial infarction and atherosclerosis.12[4], 14[5]

Phenotype Driver:

Gene-centric:APOA5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data