1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to arachidonoylcholine

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.324
Position:
61588305
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
13.753
Reference Allele:
A
-log10(P):
-97.430
MAF:
0.344
Beta (Num):
0.131
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.193
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI) anchor biosynthesis, phospholipid metabolism.4[1], 5[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Fatty acid metabolism, acetylcholine signaling modulation.8[1], 9[2], 10[3], 11[4]

Ratio Explanation:

This ratio reflects FADS1/FADS2 activity; these enzymes are crucial for producing arachidonic acid (denominator precursor), thereby influencing the balance of specific lipid species.12[1], 13[2], 3[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity modifies the balance of pro-inflammatory (e.g., arachidonic acid-derived) and pro-resolving lipid mediators, influencing the inflammatory and metabolic phenotypes observed, such as IBD, asthma, and hypercholesterolemia.14[1], 3[2], 15[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data