1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to sphingomyelin (d17:2/16:0, d18:2/15:0)*

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200125
Name: sphingomyelin (d17:2/16:0, d18:2/15:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.206
Position:
61557803
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
11.066
Reference Allele:
T
-log10(P):
-63.867
MAF:
0.346
Beta (Num):
0.127
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.079
SE (Den):
0.014
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, GPI-anchor biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Sphingolipid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio may reflect FADS1 activity, which alters the fatty acid pool, thereby influencing the balance between glycerophospholipid and sphingolipid synthesis.1[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters fatty acid desaturation, impacting the balance of lipid classes.7[1], 8[2] This dysregulation is a known risk factor for the observed lipid metabolism disorders (hypercholesterolemia, cholelithiasis) and inflammatory conditions like asthma and IBD, which are strongly associated with FADS1 function.9[3], 10[4], 11[5], 5[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data