1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to cerotoylcarnitine (c26)*

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of cerotoylcarnitine (c26)*
Metabolite Accession: GCST90200136
Name: cerotoylcarnitine (c26)*
Hmdb Id: HMDB0006347
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOCKWDDTAHPJSX

Associated Genomic Regions

Region: rs174553

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.204
Position:
61575158
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
10.743
Reference Allele:
A
-log10(P):
-60.318
MAF:
0.338
Beta (Num):
0.131
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.073
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, GPI-anchor biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.6[1], 7[2]

Ratio Explanation:

This ratio may reflect FADS1/FADS2 desaturase activity, where higher levels indicate altered long-chain polyunsaturated fatty acid synthesis relative to very-long-chain fatty acid oxidation.8[1], 9[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 gene variants influence the balance of polyunsaturated and very-long-chain fatty acids.10[1], 9[2] This altered lipid metabolism is linked to inflammation and various diseases, including inflammatory bowel disease, asthma, and cardiovascular conditions, which are observed phenotypes.8[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data