1-stearoyl-2-oleoyl-gpi (18:0/18:1)* to docosatrienoate (22:3n6)*

Numerator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.321
Position:
61588305
SE (Ratio):
0.026
Effect Allele:
G
Z-score (Ratio):
12.157
Reference Allele:
A
-log10(P):
-76.628
MAF:
0.344
Beta (Num):
0.131
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.190
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis6[1], 7[2]

Ratio Explanation:

This ratio reflects FADS desaturase activity, balancing the synthesis of long-chain PUFAs (denominator) with the composition of fatty acids in GPI anchors (numerator).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the ratio, alters polyunsaturated fatty acid (PUFA) metabolism.8[1], 6[2] This dysregulation of lipid mediators is linked to inflammatory and metabolic phenotypes like cholelithiasis and type 2 diabetes, which are strongly associated with FADS gene variants.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data