1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)* to 1-myristoyl-2-palmitoyl-gpc (14:0/16:0)

Numerator Metabolite

Structure of 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Metabolite Accession: GCST90200078
Name: 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Hmdb Id: HMDB0007883
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRQSAJRUMDQMMS

Denominator Metabolite

Structure of 1-myristoyl-2-palmitoyl-gpc (14:0/16:0)
Metabolite Accession: GCST90199653
Name: 1-myristoyl-2-palmitoyl-gpc (14:0/16:0)
Hmdb Id: HMDB0007869
Super Pathway: NA
Sub Pathway: NA
Inchikey: RFVFQQWKPSOBED

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.323
Position:
61557803
SE (Ratio):
0.012
Effect Allele:
C
Z-score (Ratio):
-26.477
Reference Allele:
T
-log10(P):
-354.011
MAF:
0.345
Beta (Num):
-0.342
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.019
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine metabolism

Ratio Explanation:

The ratio reflects the conversion of palmitic acid to arachidonic acid on a phosphatidylcholine backbone, regulated by FADS1, indicating inflammatory and metabolic pathway activity.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 gene variants influence the ratio of 1-myristoyl-2-arachidonoyl-gpc to 1-myristoyl-2-palmitoyl-gpc, affecting inflammatory and lipid pathways. This altered lipid metabolism is linked to an increased risk for benign colorectal neoplasms, likely through modulation of inflammation and cell signaling.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data